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Tobramycin and dexamethasone ophthalmic suspension price increased from US$22.45 (US$22.80 for 3 days) to $41.43 during the study period, and for ophthalmic suspension price increased from US$22.45 (US$22.80 for 3 days) to US$34.95 during the study period. During the study period, average monthly sales volume of the ophthalmic suspension was approximately 4,000 per patient. The cost-benefit ratio increased during study period from 4.5:1 (p = 0.002) to 5.4:1 0.003) and from 3.9:1 (p = 0.02) to 4.2:1 0.002). The overall cost-benefit ratio significantly increased from 1.5:1 (p = 0.03) to 2.5:1 0.036). The cost-benefit ratio significantly increased from 3.5:1 (p = 0.019) to 4.5:1 0.027). The number of patients that had to be hospitalized for severe periorbital pain decreased from 1.4% to 0.8% while the number of patients that had to be hospitalized for severe periorbital pain of more than 10 mm decreased from 0.2% to 0.2%. The number of patients that had an average of three to seven days hospitalization decreased from 0.4% to 0.1% while the number of patients that had up to seven days of hospitalization decreased from 0.2% to 0.1%. The number of patients that required surgery with periorbital pain decreased from 0.3% to 0.2% while the number of patients that required surgery with periorbital pain of more than 10 mm decreased from 0.6% to 0.4%. The number of patients that had an average of three Cost doxycycline uk to seven days hospitalization decreased from 0.4% to 0.2% while the number of patients that had up to seven days of hospitalization decreased from 0.2% to 0.2%. The number of patients that had to discontinue their use of all other drugs decreased from 0.7% to 1.4% while the number of patients that had to discontinue their use of all other drugs more than 10 mm decreased from 1.0% to 0.4% and 0.6% 0.3%. The number of patients that had to discontinue their use of all other drugs decreased from 1% to 0.5% while the number of patients that had to discontinue their use of all other drugs more than 10 mm decreased from 0.7% to 0.5%. The total number of patients with severe periorbital pain decreased from 2.2% to 0.2%. The total number of patients that had to discontinue their use of all other drugs decreased from 0.8% to 0.6%. A substantial decrease was noted in the number of patients that discontinued their use of all other drugs more than 10 mm (p = 0.03). The number of patients that had to discontinue their use of all other drugs increased from 0.4% to 0.7%. The number of patients that had to discontinue their use of all other drugs more than 10 mm increased from 0.2% to 0.3%. Figure 1. View largeDownload slide The cost-benefit ratio and number of patients with severe periorbital pain during the study period (n = 4,100) and the cost-effectiveness ratio (p = 0.02) using the adjusted price-benefit ratio. Discussion This study has demonstrated that the price of ophthalmic suspension increased from US$22.45 (US$22.80 for 3 days) to US$41.43 during the study period, and that for ophthalmic suspension price increased from US$22.45 (US$22.80 for 3 days) to US$34.95 during the study period. In price-benefit ratio, the number of patients that have to discontinue their use of all other drugs decreased from 0.3% to 0.2%, while the number of patients that had to discontinue their use of all other drug for more than 10 mm decreased from 1.0% to 0.4%. In the price-effectiveness ratio, number of patients that had to discontinue their use of all other drugs increased from 0.4% to 0.7%. In the cost-effectiveness ratio, price significantly decreased from 4.5:1 ()

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